Pharmacokinetic

Pharmacokinetic (PK) data is a key requirement in the evaluation of new drugs and formulations. A quantitative measure of drug exposure is essential for the sound interpretation of pre-clinical efficacy studies. PK data is also requisite before toxicology studies can be performed.

PK samples are collected at various time points as per protocol and analyzed for drug concentrations. The time points depending on the nature of compound and route of administration.

Species offered:

  • Mouse
  • Rat

Delivery method:

  • Single dose
  • Multiple dose
  • Infusion
  • Cassette dosing

Route of administration

  • Oral (PO)
  • Intraperitoneal (IP)
  • Subcutaneous (SC)
  • Intramuscular (IM)
  • Intravenous (IV)
  • Topical
  • Intranasal
  • Subcutaneous (SC)
  • Intraocular
  • Intra-rectal

Sampling:

  • Blood-Plasma or Serum
  • Urine
  • Feces
  • Tissue or organ

Pharmacokinetic study in disease model

Invitek offers Pharmacokinetics in disease models for better understanding of absorption and bioavailability.

Toxicokinetics

Toxicokinetics used primarily for establishing relationships between exposures in toxicology experiments in animals and corresponding exposures in humans.

Plasma samples generated in toxicology studies and the resultant concentration data used for interpreting the result using the industry-standard software.